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Kelly, K. De novo lipogenesis is essential for platelet production in humans. Lawitz, E. Acetyl-CoA carboxylase inhibitor GS for 12 weeks reduces hepatic de novo lipogenesis and steatosis in patients with nonalcoholic steatohepatitis.

Younossi, Z. Hepatology 73 , — Stine, J. Patel, J. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Savage, D. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Bergman, A. Safety, tolerability, pharmacokinetics and pharmacodynamics of a liver-targeting ACC inhibitor PF : a three-part randomized phase 1 study.

Fenofibrate mitigates increases in serum triglycerides due to the ACC inhibitor firsocostat in patients with advanced fibrosis due to NASH: a phase 2 randomized trial. Fabbrini, E. Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease.

Oscarsson, J. Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: a double-blind, randomized, placebo-controlled study. Parker, H. Effect of fish oil supplementation on hepatic and visceral fat in overweight men: a randomized controlled trial. Nutrients 11 , Lawler, P.

Atherogenic lipoprotein determinants of cardiovascular disease and residual risk among individuals with low low-density lipoprotein cholesterol. Heart Assoc. Mora, S. Atherogenic lipoprotein subfractions determined by ion mobility and first cardiovascular events after random allocation to high-intensity statin or placebo: the justification for the use of statins in prevention: an Intervention Trial Evaluating Rosuvastatin JUPITER trial.

Circulation , — Kanter, J. Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes. Brown, W. Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein. Ginsberg, H. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. Wang, C. Modulation of lipoprotein lipase activity by apolipoproteins.

Effect of apolipoprotein C-III. Yamaguchi, K. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45 , — Gluchowski, N. Hepatocyte deletion of triglyceride-synthesis enzyme acyl CoA: diacylglycerol acyltransferase 2 reduces steatosis without increasing inflammation or fibrosis in mice.

Hepatology 70 , — Le, T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 56 , — Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial MOZART trial.

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These studies were sponsored by Pfizer Inc. The authors would like to thank the patients who offered their time, interest and participation as well as the staff across all sites who recruited at least one patient in the clinical studies. The authors would also like to thank colleagues at Nordic Bioscience, M. Karsdal and D. Birnbaum for helpful discussions; K. Kelly and D. Beebe for help with in vivo studies; J. Morin and D.

Shanthappa for assistance with shear-wave elastography measurements; J. Travers and A. Robertson for histology; S. Vargas for microscopic imaging of histological sections; and P. Garnick for clinical study management. Medical writing support, under the direction of the authors, was provided by C. Roberto A. Calle, Neeta B.

Amin, Trenton T. Bence, Albert M. Kim, Jeffrey A. You can also search for this author in PubMed Google Scholar. Amin, S. Officials acknowledged those risks, but said they had no other way to identify the people accessing the sites. Lawyers for child pornography victims expressed surprise that the FBI would agree to such tactics — in part because agents had rejected them in the past — but nonetheless said they approved. The FBI hacks have drawn repeated — though so far unsuccessful — legal challenges, largely centered on the search warrants agents obtained before agents cracked the computer network.

But they have also prompted a backlash of a different kind. A federal judge is scheduled to hear arguments on that request Friday.

Federal agents first noticed Playpen not long after it went online in August, FBI agents tracked the site to computer servers in North Carolina, and in February seized the site and quietly moved it to its own facility in Newington, Va. The FBI kept Playpen online for 13 days. During that time, federal prosecutors told defense lawyers that the site included more than 23, sexually explicit images and videos of children.

If you want high-definition episodes of your favorite shows, EZTV is the place to go. We searched for older titles like Two and a Half Men, and it had a decent library of options. We even tried going for more obscure titles, like the British show Midsomer Murders.

EZTV has a large variety of torrents for the new releases in that series, plus a packages of older episodes. We tried browsing for older titles, and it has a good library, both for PC and consoles.

You can subscribe to different categories or titles and get a feed of new torrents for them. Update: Despite recent claims to the contrary, Zooqle still seems to be up and running. For instance, we received a remark from one of our French readers that Zooqle has been shut down, so we checked with a VPN if it was blocked in France. In all three instances, we were successful. Therefore, we conclude that, as of now, Zooqle is accessible to, at least, a great portion of internet users.

Needless to say, we will check this regularly and keep you updated! LimeTorrents is very good for new releases. Mirrors: limetorrents.

Not a torrent site per se, Torrends. However, we do want to praise its seamless design and minimal ad intrusion. Mirrors: None. This website used to be called torrents. Website: Torrentdownloads website. Attention: This website attempts to open an additional browser tab with advertisements.

Not harmful, but annoying. Asian titles specifically seem to take a big part of their servers. Mirrors: torrentdownloads. Lastly, and perhaps most importantly for many, private torrenting sites generally have significantly higher streaming speeds than public ones, because members have seeding quotas they need to comply with. Last but not least, Bibliotik is the largest private torrenting site for downloading ebooks.

We recommend uTorrent , but Bittorrent will work just as fine. Once you installed a torrent client, download the torrent from one of the best torrent sites in the list above, and open it using the client.

If you already installed the client, the torrent file will automatically open on this screen:. First, always download torrents and browse torrent sites using a VPN.

Read our roundup of the best VPNs and use one of those before doing any torrenting. Avoid big buttons and only click on the URL that will actually download your desired torrent file. You risk downloading malware, viruses , and even losing your information to phishing campaigns, which are very common scenarios for torrent users.

Again, check our best VPN section for the best options out there, safety tips, and news. After that, tick all the VPN safety settings you can. Make sure you enable connection encryption, leak protection, and a kill switch for when your network is at risk of getting infected.

Most VPNs will feature these options just maybe under different names. The kill switch is important, as it will prevent your identity from being exposed when your VPN connection suddenly drops. Third, install an ad blocker and other safety-enhancing extensions. You can read all about them in our article detailing the best browser extensions for safety and privacy , as well as our guide with 8 steps to stay safe online.

A lot of countries have their own regional private torrent site, and they all seem impossible to get in. We took a deep dive into the world of private torrent sites, and we were able to obtain invitations for some of them. Reddit, 8chan, and specifically anonymity-focused forums have threads on torrenting. Rarely, invitations will be just thrown there for a limited time, but what we did is we got in touch with someone that implied having an account in one of their threads.

Ideally, you already know someone who has an account there, and you can ask for an invitation.



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